A marijuana component helps mitigate cocaine addiction in mice, according to a new study, lending further evidence to the notion that marijuana is an “exit” drug and could become the next big anti-addiction therapy.
Posts Tagged ‘marijuana health’
Medical Marijuana Inc announced today that as of August 1, 2011 its initial Cannabidiol (CBD) and THC Free Product lines will be available for consumers in the United States.
The first lines of products are to be distributed to more than two thousand health and wellness centers throughout the United States as well as direct to consumers through the Hemp Network, a division of Medical Marijuana Inc ( http://www.thehempnetwork.com ). The products will be available in a CBD tablet, CBD capsule, and CBD-infused beverage line, all which carry the health and wellness benefits of CBD cannabis extract.
For more information about the health benefits of Cannabidiol (CBD) please visit the following United States Health Department Patent # 6,630,507, titled “Cannabis as Antioxidants and Neuroprotectants” (see http://tinyurl.com/6hwwmt ). This article explains many of the benefits of Cannabis and specifically Cannabidiol (CBD).
Medical Marijuana Inc is reviewing the previous offers from distributors for these products in China and Europe, negotiations are expected to conclude by August 1, 2011.
ABOUT MEDICAL MARIJUANA INC
Our mission is to be the world’s premier cannabis and hemp industry innovators, leveraging our team of professionals to source, evaluate, invest in and purchase value-added sustainable companies, while allowing them to keep their integrity and entrepreneurial spirit. We strive to create awareness within our industry, pay homage to the visionaries and activists of the past and present, provide the platform from which the industry can emerge into a global sustainable economy for all. Medical Marijuana Inc recognizes the vast and unequaled opportunities that exist in the rapidly expanding hemp and medical marijuana industries. The scientific recognition of cannabis has brought legalized marijuana use to the forefront of mainstream discussion, thus opening the door for safe and lucrative investment opportunities.
|Photo: The Julius Axelrod Papers|
|Dr. Julius Axelrod, pictured above, conducted some of the original research which culminated in the United States government getting a patent on all cannabinoids in 2003.|
|Graphic: TRENDS In Pharmacological Sciences|
|Pharmacological actions of non-psychotropic cannabinoids (with the indication of the proposed mechanisms of action). Abbreviations: D 9 -THC, D 9 -tetrahydrocannabinol; D 8 -THC, D 8 -tetrahydrocannabinol; CBN, cannabinol; CBD, cannabidiol; D 9 -THCV, D 9 -tetrahydrocannabivarin; CBC, cannabichromene; CBG, cannabigerol; D 9 -THCA, D 9 -tetrahydrocannabinolic acid; CBDA, cannabidiolic acid; TRPV1, transient receptor potential vanilloid type 1; PPARg, peroxisome proliferator-activated receptor g; ROS, reactive oxygen species; 5-HT1A, 5-hydroxytryptamine receptor subtype 1A; FAAH, fatty acid amide hydrolase. (+), direct or indirect activation; “, increase; #, decrease.|
|Skin immediately after exposure to 30 percent hydrogen peroxide|
Hydrogen peroxide‘s actions come from the fact that it oxidizes tissue.
|Dr. Julius Axelrod|
|Photo: KOMO News|
|Congressional candidate Roger Goodman, left,
advocates the legalization of marijuana and protecting the planet.
What if we could elect a real, live drug policy reformerto Congress? A candidate who has that background — and unabashedly advocates the legalization of cannabis nationwide — is running for the U.S. House of Representatives from Washington state, and he has an excellent chance to win.
|Photo: Roger Goodman For Congress|
|Roger Goodman: “We need to pay attention to planetary health”|
“Nationwide, about 7 or 8 billion dollars is spent just on marijuana enforcement,” he told me. “That money could certainly be better used. But I don’t stress the savings; I’m really more concerned about public safety, children and families.
|Photo: Pete Kuhns/Seattle Weekly|
|Rep. Roger Goodman shows off a stash of his drug of choice: chocolate.|
“In Washington state, we put about 8,000 people in cages every year who either should just be left alone, or should be receiving mental health or substance abuse treatment,” Goodman said. “We have a lot of progress that needs to be made.”
|Photo: The Stranger|
|Rep. Roger Goodman:
“We’ve driven patients back to the streets.
Do we want the drug dealer model, or do we want the safe access point model?”
|Graphic: Roger Goodman For Congress|
|Photo: Roger Goodman For Congress|
Another big concern for marijuana activists in the New Approach Washington measure’s language is the fact that while it would allow adults to buy pot at state-run stores, it still wouldn’t allow home cultivation of recreational cannabis.
The presence of a man like Roger Goodman in Congress could make a major difference going forward as our nation discovers the way to a saner approach on marijuana.
The long-term administration of delta-9-THC, the primary psychoactive compound in marijuana, is associated with decreased mortality in monkeys infected with the simian immunodeficiency virus (SIV), a primate model of HIV (human immunodeficiency virus) disease, according to in vivo experimental trial data published in the June issue of the journal AIDS Research and Human Retroviruses.
Investigators at the Louisiana State University Health Sciences Center assessed the impact of chronic intramuscular THC administration compared to placebo on immune and metabolic indicators of SIV disease during the initial six-month phase of infection.
Researchers reported, “Contrary to what we expected, … delta-9-THC treatment clearly did not increase disease progression, and indeed resulted in generalized attenuation of classic markers of SIV disease.” Authors also reported that THC administration was associated with “decreased early mortality from SIV infection” and “retention of body mass.”
Investigators concluded, “These results indicate that chronic delta-9-THC does not increase viral load or aggravate morbidity and may actually ameliorate SIV disease progression.”
Clinical trials have previously documented that the short-term inhalation of cannabis does not adversely impact viral loads in HIV patients, and may even improve immune function.
For more information, please contact Paul Armentano, NORML Deputy Director, at: firstname.lastname@example.org. Full text of the study, “Cannabinoid administration attenuates the progression of simian immunodeficiency virus,” is available online here:http://www.liebertonline.com/doi/pdf/10.1089/aid.2010.0218. Additional studies documenting the disease modifying potential of marijuana is available in the NORML handbook, Emerging Clinical Applications For Cannabis & Cannabinoids: Fourth Edition, available online at: http://norml.org/index.cfm?Group_ID=7002.
A reader asked us to pass along this man’s amazing story. Here is what I could dig up. The first story is the start, the second is the result, and the third part is another explanation of the case:
By Jeffrey W. Kennedy (found at medicalmarijuana411.com)
My name is Jeffrey w Kennedy. I am disabled.
I suffer from very Painful Neuropathy of the Feet & Legs, Failed Back Surgery & Depression.
I live in Palm Beach County, Florida, Which is where I was arrested for trying to grow Medical Marijuana, (26 plants) they claim.
It all started August 29th 2009 when our home was burglarized. I came home to find the front door open. I thought the burglar(s) may still be in our home. I am the owner of a (38) Caliber Hand Gun with a permit to carry, of which I had left at home that day.
In fear of being shot with my own gun, I called the Boynton Beach Police. They arrived and cleared our home.
Although the burglar(s) had fled with over $20,000.00 of cash, jewelry and electronics, the police told me to sit and not to move. They began to question me as if I had robbed my own home. They then began to question me about my Marijuana use.
Rather then telling them a lie, I told them that I did use Medical Marijuana as I am disabled and suffer from very Painful Neuropathy of the Feet & Legs, and Medical Marijuana is the only thing that seems to stop that Pain.
Soon after my explanation, they claim they discovered my medical garden and arrested me. The State of Florida is now charging me with Trafficking. I have hired Attorney Michael c Minardi to handle my defense.
Trial has been delayed for the second time now. My Attorney on December 13th 2010 will appear for a Status Check, at that time a New Trial Date should be rescheduled for early next year in Palm Beach County, Florida court room.
The Honorable Judge Miller is allowing, The Medical Necessity Defense.
This Defense has never been tried in a Palm Beach County Court.
We have some Experts in place, but our looking to add more. And we our in need of Public Support & Donations.
If you feel you have the Compassion to assist or help tell my story or Donate to my Legal Fund, A Non-Profit Tax Deductable Account has been set up at any Bank Atlantic.
Thank you for your time, concern & generosity.
Jeffrey W Kennedy
From Jeffery Kennedy – Trial Dismissed!!
BREAKING NEWS – From our friend, Jeffery Kennedy:
HISTORICAL MEDICAL CANNABIS TRIAL HAS BEEN DISMISSED!!!!!!!!! The State Has Decided To Dismiss All Charges On Jeffrey Kennedy ! This Could Not Have Been Done With Out The Support Of All.
And For That My Wife And I Thank Everyone Involved !
…Please Be Safe,
Jeffrey & Sharon Kennedy
I started with just a few supporters that believed in me. Those Few Supporters Have Turned Into Thousands. And From That Support, Our Voices Have Now Been Heard As One. And The State Of Florida, Now Knows That I am Not A Criminal. And For That I Am Grateful.
Thank you to everybody that believed in me and in this fight for Medical Cannabis and the right to choose over Opiates. All though no laws have been changed, I think they (government) are taking notice. That Cannabis Has Many Quality Medical Benefits And The Laws Will Change Soon Every Where.
Thank You & Be Safe,
Jeffrey & Sharon Kennedy
Pot charges dropped for Boynton Beach man
BOYNTON BEACH, Fla. — 53-year-old Jeff Kennedy was prepared to spend five years in prison for growing marijuana for medical reasons. But on Friday, Kennedy showed up in court wearing a t-shirt stating, ‘I am a patient not a criminal,’ and it turns out the state agrees. The state dropped the charges at the last minute.
“I’m just going to go forward and advocate for medical cannabis,” said Kennedy.
Kennedy suffers from chronic pain caused by a botched back surgery. His legs burn and twitch constantly. Doctors have prescribed him a cocktail of highly addictive and dangerous pain killers.
“It is slowly killing me,” said Kennedy.
Kennedy says marijuana works better than his prescription meds and do not have the dangerous side affects. Kennedy’s attorney says today’s dismissal proves other patients who use medical marijuana have a proven legal defense to do so.
“Anybody else who may be in similar situations, they know now or can be educated that they do have a defense if they do want to use cannabis,” said Michael Minardi, Kennedy’s lawyer.
Jeff says he will continue to fight until it’s legal to use medical marijuana in the state. Just like it already is in 15 other states and the district of columbia.
“Take this all the way and standup not for my rights and disabled person in the state of florida that can benefit from cannabis.”
But the state’s attorney’s office says not so fast. Attorney Jill Richstone spoke with WPEC and said, “There is no policy that we are accepting a medical marijuana defense. We look at each case individually.”
Richstone went on to say it was decided not to continue on with a trial because Jeff kennedy did not have a grow house to sell marijuana to other people.
A senior citizen “pot collective” is facing growing criticism in a Southern California retirement community, highlighting disparate viewpoints about marijuana in older Americans.
(LIST: Stoner Cinema)
In a classic tale of old people who want to get a little stoned, 150 residents of the 18,000-person gated retirement community Laguna Woods Village set up a little weed distribution plan. The only problem: the Golden Rain Foundation, the group of volunteers that governs the residential community, disallowed the cultivation of marijuana in the development’s gardens.
Per their state-mandated legal right, any of those seniors who have medical marijuana cards may grow up to six mature plants per person in their private residences. Despite this, their usage – whether medical or otherwise – has not been universally accepted in the community with an average age of 78.
“This did stir up a lot of feelings,” Laguna Woods Village resident Susan Margolis, 67, told the Associated Press. “There are a lot of people that have never used marijuana and there are younger people who have used marijuana who say, ‘Come on now, this is just ridiculous.’”
Woods said that the attitude towards marijuana was primarily split along generational lines. Residents of the community must be at least 55 to move in.
After the communal growing plan was nixed by the community’s governing board, members of the senior pot collective tried to run their own greenhouse in a rented facility away from Laguna Woods Village, but they reportedly lost thousands of dollars worth of marijuana when a light was plugged into the wrong outlet.
In another attempt at having a steady supply, some seniors gave seedlings to a grower operating a greenhouse in Los Angeles, but the police shut down the facility and the plants were destroyed.
(PHOTOS: Cannabis Conventions)
After that incident, a collective member began two off-site greenhouses, the location of which the seniors refused to disclose to the Associated Press. According to one member, the marijuana is sold to collective members on a sliding scale predicated on need and ability to pay. Prices range from $35 an ounce to about $200 an ounce.
But while collective members are smoking strains with names like “Sour Tsunami,” many are dealing with debilitating health problems. Several regular users told the AP that they suffered from osteoarthritis, debilitating nausea and the after-effects of a stroke.
It is this pain, rather than a desire to be stoned, that drives many members of the pot collective to grow and smoke marijuana.
“Look, whether it’s a legal thing or not a legal thing, it helps you. I am 90 years old and I don’t mind talking about it,” collective member Joe Schwartz told the AP.
Schwartz’s is an attitude that is growing in popularity among seniors throughout the country. A series of surveys from the Substance Abuse and Mental Health Services Administration showed that the number of people aged 50 and older who reported marijuana use in the prior year went up from 1.9% to 2.9% from 2002 to 2008.
|Graphic: The Truth Source|
Welcome to Room 420, where your instructor is Mr. Ron Marczyk and your subjects are wellness, disease prevention, self actualization, and chillin’.
|Photo: THC Finder|
NORML Foundation/Senior Policy Analyst“Cannabinoids possess … anticancer activity [and may] possibly represent a new class of anti-cancer drugs that retard cancer growth, inhibit angiogenesis (the formation of new blood vessels) and the metastatic spreading of cancer cells.” So concludes a comprehensive review published in the October 2005 issue of the scientific journal Mini-Reviews in Medicinal Chemistry.Not familiar with the emerging body of research touting cannabis’ ability to stave the spread of certain types of cancers? You’re not alone.For over 30 years, US politicians and bureaucrats have systematically turned a blind eye to scientific research indicating that marijuana may play a role in cancer prevention — a finding that was first documented in 1974. That year, a research team at the Medical College of Virginia (acting at the behest of the federal government) discovered that cannabis inhibited malignant tumor cell growth in culture and in mice. According to the study’s results, reported nationally in an Aug. 18, 1974, Washington Post newspaper feature, administration of marijuana’s primary cannabinoid THC, “slowed the growth of lung cancers, breast cancers and a virus-induced leukemia in laboratory mice, and prolonged their lives by as much as 36 percent.”Despite these favorable preclinical findings, US government officials dismissed the study (which was eventually published in the Journal of the National Cancer Institute in 1975), and refused to fund any follow-up research until conducting a similar — though secret — clinical trial in the mid-1990s. That study, conducted by the US National Toxicology Program to the tune of $2 million concluded that mice and rats administered high doses of THC over long periods experienced greater protection against malignant tumors than untreated controls.Rather than publicize their findings, government researchers once again shelved the results, which only came to light after a draft copy of its findings were leaked in 1997 to a medical journal, which in turn forwarded the story to the national media.Nevertheless, in the decade since the completion of the National Toxicology trial, the U.S. government has yet to encourage or fund additional, follow up studies examining the cannabinoids’ potential to protect against the spread cancerous tumors.Fortunately, scientists overseas have generously picked up where US researchers so abruptly left off. In 1998, a research team at Madrid’s Complutense University discovered that THC can selectively induce apoptosis (program cell death) in brain tumor cells without negatively impacting the surrounding healthy cells. Then in 2000, they reported in the journal Nature Medicine that injections of synthetic THC eradicated malignant gliomas (brain tumors) in one-third of treated rats, and prolonged life in another third by six weeks.In 2003, researchers at the University of Milan in Naples, Italy, reported that non-psychoactive compounds in marijuana inhibited the growth of glioma cells in a dose dependent manner and selectively targeted and killed malignant cancer cells.The following year, researchers reported in the journal of the American Association for Cancer Research that marijuana’s constituents inhibited the spread of brain cancer in human tumor biopsies. In a related development, a research team from the University of South Florida further noted that THC can also selectively inhibit the activation and replication of gamma herpes viruses. The viruses, which can lie dormant for years within white blood cells before becoming active and spreading to other cells, are thought to increase one’s chances of developing cancers such as Karposis Sarcoma, Burkitts lymphoma, and Hodgkins disease.More recently, investigators published pre-clinical findings demonstrating that cannabinoids may play a role in inhibiting cell growth of colectoral cancer, skin carcinoma, breast cancer, and prostate cancer, among other conditions. When investigators compared the efficacy of natural cannabinoids to that of a synthetic agonist, THC proved far more beneficial – selectively decreasing the proliferation of malignant cells and inducing apoptosis more rapidly than its synthetic alternative while simultaneously leaving healthy cells unscathed.Nevertheless, US politicians have been little swayed by these results, and remain steadfastly opposed to the notion of sponsoring – or even acknowledging – this growing body clinical research, preferring instead to promote the unfounded notion that cannabis use causes cancer. Until this bias changes, expect the bulk of research investigating the use of cannabinoids as anticancer agents to remain overseas and, regrettably, overlooked in the public discourse.”
Gliomas/Brain Cancerby Paul ArmentanoNORML Foundation/Senior Policy AnalystGliomas (tumors in the brain) are especially aggressive malignant forms of cancer, often resulting in the death of affected patients within one to two years following diagnosis. There is no cure for gliomas and most available treatments provide only minor symptomatic relief.A review of the modern scientific literature reveals numerous preclinical studies and one pilot clinical study demonstrating cannabinoids’ ability to act as anti-neoplastic agents, particularly on glioma cell lines.Writing in the September 1998 issue of the journal FEBS Letters, investigators at Madrid’s Complutense University, School of Biology, first reported that delta-9-THC induced apoptosis (programmed cell death) in glioma cells in culture. Investigators followed up their initial findings in 2000, reporting that the administration of both THC and the synthetic cannabinoid agonist WIN 55,212-2 ”induced a considerable regression of malignant gliomas” in animals. Researchers again confirmed cannabinoids’ ability to inhibit tumor growth in animals in 2003.That same year, Italian investigators at the University of Milan, Department of Pharmacology, Chemotherapy and Toxicology, reported that the non-psychoactive cannabinoid, cannabidiol (CBD), inhibited the growth of various human glioma cell lines in vivo and in vitro in a dose dependent manner. Writing in the November 2003 issue of the Journal of Pharmacology and Experimental Therapeutics Fast Forward, researchers concluded, “Non-psychoactive CBD … produce[s] a significant anti-tumor activity both in vitro and in vivo, thus suggesting a possible application of CBD as an anti neoplastic agent.”In 2004, Guzman and colleagues reported that cannabinoids inhibited glioma tumor growth in animals and in human glioblastoma multiforme (GBM) tumor samples by altering blood vessel morphology (e.g., VEGF pathways). Writing in the August 2004 issue of Cancer Research, investigators concluded, “The present laboratory and clinical findings provide a novel pharmacological target for cannabinoid-based therapies.”
In addition to cannabinoids’ ability to moderate glioma cells, separate studies demonstrate that cannabinoids and endocannabinoids can also inhibit the proliferation of other various cancer cell lines, including breast carcinoma,[11-15] prostate carcinoma,[16-18] colorectal carcinoma, gastric adenocarcinoma, skin carcinoma, leukemia cells,[22-23]neuroblastoma, lung carcinoma,[25-26] uterus carcinoma, thyroid epithelioma, pancreatic adenocarcinoma,[29-30], cervical carcinoma, oral cancer, biliary tract cancer (cholangiocarcinoma) and lymphoma.[34-35]Studies also indicate that the administration of cannabinoids, in conjunction with conventional anti-cancer therapies, can enhance the effectiveness of standard cancer treatments. Most recently, investigators at the University of California, Pacific Medical Center reported that cannabinoids possess synergistic anti-cancer properties — finding that the administration of a combination of the plant’s constituents is superior to the administration of isolated compounds alone.Consequently, many experts now believe that cannabinoids “may represent a new class of anticancer drugs that retard cancer growth, inhibit angiogenesis and the metastatic spreading of cancer cells.”[38-39]
 Guzman et al. 1998. Delta-9-tetrahydrocannabinol induces apoptosis in C6 glioma cells. FEBS Letters 436: 6-10.
 Guzman et al. 2000. Anti-tumoral action of cannabinoids: involvement of sustained ceramide accumulation and extracellular signal-regulated kinase activation. Nature Medicine 6: 313-319.
4] Massi et al. 2004. Antitumor effects of cannabidiol, a non-psychotropic cannabinoid, on human glioma cell lines.Journal of Pharmacology and Experimental Therapeutics Fast Forward 308: 838-845.
5] Guzman et al. 2004. Cannabinoids inhibit the vascular endothelial growth factor pathways in gliomas (PDF). Cancer Research 64: 5617-5623.
 Allister et al. 2005. Cannabinoids selectively inhibit proliferation and induce death of cultured human glioblastoma multiforme cells. Journal of Neurooncology 74: 31-40.
 Guzman et al. 2006. A pilot clinical study of delta-9-tetrahydrocannabinol in patients with recurrent glioblastoma multiforme. British Journal of Cancer (E-pub ahead of print).
8] Parolaro and Massi. 2008. Cannabinoids as a potential new drug therapy for the treatment of gliomas. Expert Reviews of Neurotherapeutics 8: 37-49
 Galanti et al. 2007. Delta9-Tetrahydrocannabinol inhibits cell cycle progression by downregulation of E2F1 in human glioblastoma multiforme cells. Acta Oncologica 12: 1-9.
 Calatozzolo et al. 2007. Expression of cannabinoid receptors and neurotrophins in human gliomas. Neurological Sciences 28: 304-310.
 Cafferal et al. 2006. Delta-9-Tetrahydrocannabinol inhibits cell cycle progression in human breast cancer cells through Cdc2 regulation. Cancer Research 66: 6615-6621.
 Di Marzo et al. 2006. Anti-tumor activity of plant cannabinoids with emphasis on the effect of cannabidiol on human breast carcinoma. Journal of Pharmacology and Experimental Therapeutics Fast Forward 318: 1375-1387.
 De Petrocellis et al. 1998. The endogenous cannabinoid anandamide inhibits human breast cancer cell proliferation. Proceedings of the National Academy of Sciences of the United States of America 95: 8375-8380.
 McAllister et al. 2007. Cannabidiol as a novel inhibitor of Id-1 gene expression in aggressive breast cancer cells.Molecular Cancer Therapeutics 6: 2921-2927.
 Cafferal et al. 2010. Cannabinoids reduce ErbB2-driven breast cancer progression through Akt inhibition.Molecular Cancer 9: 196.
 Sarfaraz et al. 2005. Cannabinoid receptors as a novel target for the treatment of prostate cancer. Cancer Research 65: 1635-1641.
 Mimeault et al. 2003. Anti-proliferative and apoptotic effects of anandamide in human prostatic cancer cell lines.Prostate 56: 1-12.
 Ruiz et al. 1999. Delta-9-tetrahydrocannabinol induces apoptosis in human prostate PC-3 cells via a receptor-independent mechanism. FEBS Letters 458: 400-404.
 Pastos et al. 2005. The endogenous cannabinoid, anandamide, induces cell death in colorectal carcinoma cells: a possible role for cyclooxygenase-2. Gut 54: 1741-1750.
 Di Marzo et al. 2006. op. cit
 Casanova et al. Inhibition of skin tumor growth and angiogenesis in vivo by activation of cannabinoid receptors. 2003. Journal of Clinical Investigation 111: 43-50.
 Powles et al. 2005. Cannabis-induced cytotoxicity in leukemic cell lines. Blood 105: 1214-1221
 Jia et al 2006. Delta-9-tetrahydrocannabinol-induced apoptosis in Jurkat leukemic T cells in regulated by translocation of Bad to mitochondria. Molecular Cancer Research 4: 549-562.
 Preet et al. 2008. Delta9-Tetrahydrocannabinol inhibits epithelial growth factor-induced lung cancer cell migration in vitro as well as its growth and metastasis in vivo. Oncogene 10: 339-346.
 Baek et al. 1998. Antitumor activity of cannabigerol against human oral epitheloid carcinoma cells. Archives of Pharmacal Research: 21: 353-356.
 Carracedo et al. 2006. Cannabinoids induce apoptosis of pancreatic tumor cells via endoplasmic reticulum stress-related genes. Cancer Research 66: 6748-6755.
 Michalski et al. 2008. Cannabinoids in pancreatic cancer: correlation with survival and pain. International Journal of Cancer 122: 742-750.
 Ramer and Hinz. 2008. Inhibition of cancer cell invasion by cannabinoids via increased cell expression of tissue inhibitor of matrix metalloproteinases-1. Journal of the National Cancer Institute 100: 59-69.
 Whyte et al. 2010. Cannabinoids inhibit cellular respiration of human oral cancer cells. Pharmacology 85: 328-335.
 Leelawat et al. 2010. The dual effects of delta(9)-tetrahydrocannabinol on cholangiocarcinoma cells: anti-invasion activity at low concentration and apoptosis induction at high concentration. Cancer Investigation 28: 357-363.
 Gustafsson et al. 2006. Cannabinoid receptor-mediated apoptosis induced by R(+)-methanandamide and Win55,212 is associated with ceramide accumulation and p38 activation in mantle cell lymphoma. Molecular Pharmacology 70: 1612-1620.
 Gustafsson et al. 2008. Expression of cannabinoid receptors type 1 and type 2 in non-Hodgkin lymphoma: Growth inhibition by receptor activation. International Journal of Cancer 123: 1025-1033.
 Liu et al. 2008. Enhancing the in vitro cytotoxic activity of Ä9-tetrahydrocannabinol in leukemic cells through a combinatorial approach. Leukemia and Lymphoma 49: 1800-1809.
 Marcu et al. 2010. Cannabidiol enhances the inhibitory effects of delta9-tetrahydrocannabinol on human glioblastoma cell proliferation and survival. Molecular Cancer Therapeutics 9: 180-189.
 Sarafaraz et al. 2008. Cannabinoids for cancer treatment: progress and promise. Cancer Research 68: 339-342.
|Photo: Ron Marczyk|
|Mr. Worth Repeating: former NYPD cop, former high school health teacher, the unstoppable Ron Marczyk, R.N., Toke of the Town columnist|
Editor’s note: Ron Marczyk is a retired high school health education teacher who taught Wellness and Disease Prevention, Drug and Sex Ed, and AIDS education to teens aged 13-17. He also taught a high school International Baccalaureate psychology course. He taught in a New York City public school as a Drug Prevention Specialist. He is a Registered Nurse with six years of ER/Critical Care experience in NYC hospitals, earned an M.S. in cardiac rehabilitation and exercise physiology, and worked as a New York City police officer for two years. Currently he is focused on how evolutionary psychology explains human behavior.