Posts Tagged ‘THC’
|Graphic: TRENDS In Pharmacological Sciences|
|Pharmacological actions of non-psychotropic cannabinoids (with the indication of the proposed mechanisms of action). Abbreviations: D 9 -THC, D 9 -tetrahydrocannabinol; D 8 -THC, D 8 -tetrahydrocannabinol; CBN, cannabinol; CBD, cannabidiol; D 9 -THCV, D 9 -tetrahydrocannabivarin; CBC, cannabichromene; CBG, cannabigerol; D 9 -THCA, D 9 -tetrahydrocannabinolic acid; CBDA, cannabidiolic acid; TRPV1, transient receptor potential vanilloid type 1; PPARg, peroxisome proliferator-activated receptor g; ROS, reactive oxygen species; 5-HT1A, 5-hydroxytryptamine receptor subtype 1A; FAAH, fatty acid amide hydrolase. (+), direct or indirect activation; “, increase; #, decrease.|
|Power Flower strain|
|Graphic: How Stuff Works|
|Graphic: Americans for Safe Access|
|Photo: Top News|
|Sites of action of cannabinoids in the enteric nervous system. CB2 receptors indicated with the marijuana leaf.|
|How THC/cannabidiol activates the CB1/2 receptors to shut down colon cancer by signaling cancer cells to self-destruct|
|Graphic: CMR Journal|
|Schematic illustration of the functional roles of the endocannabinoid system (ECS) in the gastrointestinal tract. The ECS regulates four major functional elements in the gut: motility, secretion, inflammation, and sensation in health and disease. Major components of the ECS that have been defined in each of these functional roles are shown: CB1 and CB2 receptors, anandamide (AEA), fatty acid amide hydrolase (FAAH), and the endocannabinoid membrane transporter (EMT). For motility, the CB2 receptors only appear to be active under pathophysiological conditions and are shown italicized.|
|Graphic: Medicinal Cannabis|
|Graphic: Fit Body Bootcamp|
|Graphic: Cannabis N.I.|
|Not only is CBD cardioprotective — it is also an anti-epileptic, sedative, anxiolytic, antipsychotic, antioxidant, neuroprotectant, anti-inflammatory, anti-diabetic, anti-emetic, and anti-tumorant.|
Public-health researchers say the federal government is slowing the search for cures to breast, colon, prostate and brain cancers, as well as Huntington’s disease, Alzheimer’s, and HIV, because the research involves cannabis.
That’s the takeaway from the 21st annual symposium of the International Cannabinoid Research Society, which was held earlier this month in Illinois. Researchers stacked the program with talks not only about cannabis’s palliative properties but also its curative efficacy. The event, sponsored by the National Institute on Drug Abuse, was held the same week the Drug Enforcement Administration reiterated its stance that marijuana has no accepted medical use.
“It was really interesting,” said Amanda Reiman, who holds a doctorate from the UC Berkeley School of Social Welfare and presented at the symposium. “At the same time [that] the DEA was publicly declaring that cannabis has no medical value, I was surrounded by the most brilliant minds in the world talking about nothing but the medical value of cannabinoids.”
She said the frustration “was something you could feel in the air.”
Reiman researches medical-cannabis dispensaries as community-health providers and considers the use of cannabis a substitute for alcohol and other drugs. It’s a topic of key interest to both the International Cannabinoid Research Society and the National Institute on Drug Abuse because—unlike almost every other drug—the NIDA can completely restrict researchers’ access to cannabis, citing the plant’s danger to society.
That means safe, effective treatments that stem from pot are being held up. Take the case of Sativex, the marijuana-based mouth spray made by GW Pharmaceuticals in Europe that helps patients with multiple sclerosis and is very safe. Sufferers won’t see it in the United States any time soon, because it contains cannabinoids.
According to the abstracts of the ICRS symposium, researchers have found that the molecules in pot can reverse cancer growth. “Mechanisms of the Anti-cancer Effects of Cannabidiol and Other Non-psychotropic Cannabinoids on Human Prostate Carcinoma” reads one abstract title. There are at least a seven such papers this year.
The molecule in pot called cannabidiol, or CBD, has been shown to reduce anxiety and halt the progression of HIV in monkeys, as well as treat Crohn’s disease and ulcerative colitis, according to ICRS research. Cannabinoid researchers are investigating using pot molecules to treat head and neck squamous cell carcinomas.
But these researchers aren’t allowed to progress past animal studies and cannot get their hands on the plant, Reiman said. And it’s driving them crazy.
Since the conference was sponsored by the drug warriors at NIDA, “There was a lot of push-back from researchers in terms of restricting access to these cannabinoids, especially CBD, which is not psychoactive,” said Reiman. “There’s opportunities to cure diseases like cancer, but also neurodegenerative diseases and HIV.”
However, “A lot of NIDA’s mission is to discover the harms associated with drugs of abuse [though not alcohol] and to prevent people from using drugs and to help people who are using them to stop them.
“Nowhere in that mission is it to discover potentially therapeutic benefits for illicit drugs, and that’s why cannabis research falls into the crack,” she said.
It’s unfortunate, because pot may birth the all-star “smart drugs” of the 21st century. The molecules in marijuana stimulate a sort of intracellular Internet called the “endocannabinoid system.” Discovered in the ’90s, the endocannabinoid system runs throughout the bodies of mammals, with a large amount of receptors in the nervous system in the head and gut.
Scientists think pot molecules such as CBD can help facilitate cellular communication, assisting cells in sending signals like “Turn off the inflammation” and “My neighbor is a tumor, kill him!”
“Cannabis seeks out disregulation, like the growth of a tumor, and addresses that problem without interrupting the rest of the body,” Reiman said.
While the federal government still schedules cannabis as a Schedule I narcotic, some 1 million U.S. medical-marijuana patients have embraced the so-called vigilante medicine, as it were. And they’re not turning back, no matter what the federal government does.
“They can’t put the whole plant medical-cannabis genie back in the bottle,” Reiman said. “They just have to recognize that it’s there.”
Image via link.
This story is coming out off Battle Creek, Michigan. Last year after a workplace injury, Joseph Casias, age 30, was fired after THC was found in his system in a routine drug screening. Now Joseph is a seriously ill cancer patient, and only used the herb after work to help with pain. And he was using it upon the recommendation he received from his oncologist! But that wasn’t enough for the corporate giant Walmart, no. To them he’s just another criminal, not a patient. Walmart even tried to deny Joseph his unemployment benefits, but failed. This type of injustice just shows how shaky the laws that are supposed to protect patients can be, and how desperatley our country needs change. For the full story, click here.
“I just don’t understand why it is so bad to use something that helps me and many others who suffer with illnesses and pain,” Casias said. ”Why would you not want to help people who are suffering with high levels of pain? Where is the compassion for your fellow man?”
“Medical marijuana helps me and a lot of others, and I am grateful for every person who helps sick patients with their medicine and information on medical marijuana, because without people like them I would not know what I know today,” Casias said.
On Tuesday, July 12 I will reach a marijuana review milestone. Having pen & published 150 marijuana reviews. That includes marijuana photo galleries too. The last two reviews published, Cindy Bubbles and DJ Short’s Blueberry were donation from cannabis growers I know. From their personal head stash. Review 150 is another personal grower donation. Their samples were awesome. l am developing an excellent nug network of people who want to show off their efforts. Always looking for more. You can send your product to be reviewed to 1161 St. Clair Ave West, Toronto, ON, M6E 1B2.
I always write my reviews under the influence of the marijuana being reviewed. Usually rocking out on Blip to get the beat of my words down. If I had it together I would return to my original career as a music critic and do cannabis and album reviews. Rock out to a album to be reviewed while vaporizing marijuana also being reviewed. My influence is to take a music critic approach to my weed reviews. With a bit of food critic thrown in. Note, the music critic is sent everything. Developing a pallet takes time. Publicists pester professional critics (not food ones), offer dinners, passes and the like to curry favor. If weed arrived around here at the pace music, movies and other culture sent to alt-weeklies like NOW I’d have to hire a staff.
It’s more difficult to be critical with weed because it’s generally all very, very, good. The people handing me buds are proud of their homegrown grass. They want to show someone who will appreciate it by photographing and blogging their senses. In other words I’m getting cream.
Rarely am I afforded an opportunity to review the same strain twice. I’ve had a few strains several times now. Especially my favorite Jean Guy. I can even identify her.
Then exactly what are we judging? The grower, the genetics or the bud. Or combination of all three. I believe all of the above. Some weed is well grown, but doesn’t do diddly for my health condition or have a solid marijuana high. Then there’s weed that works for me and isn’t well grown. Flush your plants! Breeders do produce strains that do just suck Cartman’s balls.
Marijuana grown by two different people will produce different results. Based on skill level, nutrients and soil. Presuming both received equal genetics. One growers seed maybe fresh and vibrant while another receives old tired beans.
A goal we have is to hold a grower competition involving the same strain. Everyone picks up their clone on the same day and returns 90 later with finished result. With the clone producer not allowed to compete as they grew the mother plant.
If any of you are old enough, you might remember the Reese’s Peanut Butter Cups commercial, “You got your chocolate in my peanut butter!” The ad ended with the tagline, “Two great tastes that taste great together.” That’s how I feel about Reeferpunk. Whether you end up preferring punk in your reefer or reefer in your punk, from now on they just gotta go together.
|Author David Mark Brown is writing a series of alternate history “Reeferpunk” novels, “Fistful of Reefer” being the first.|
The use of medical marijuana to relieve nausea is well established, both anecdotally and from research papers. Both THC and cannabinoids are known to mitigate nausea, and smoking weed gives better relief from vomiting that taking THC orally.
A two studies undertaken in 2007 revealed that THC improves appetite and reduced weight loss in AIDS patients and smoking medical marijuana led to an increased intake of cannabis and weight gain.
As nausea and vomiting are side-effects of many treatments and symptoms of many illnesses, marijuana is a powerful drug to have in the medical armory and a synthetic form of THC to be taken in oral form was created for this very reason. However, the majority of patients prefer to smoke or vaporize ‘real’ cannabis instead of taking the artificial form.
What is most exciting about the link between weed and nausea is the fact that in cases where standard anti-emetics have failed to provide any relief, medical marijuana did the job. A recent study published in the New York State Journal of Medicine reported on 56 patients who were given marijuana following the failure of traditional anti-emetic drugs to relieve their sickness. The astounding result was a 78% success rate in this group of patients after smoking medical marijuana.
How to I use Medical Marijuana for my Nausea
Your very first action, if you are thinking about treating your nausea with medical marijuana, is to check out the medical marijuana state laws where you live. Despite the evidence of its usefulness in this situation, nausea doesn’t appear on the qualifying medical conditions of every state.
Having said that, you may well find that your primary condition – the illness which is causing you to feel sick and/or vomit – does appear on the approved list. Cancer, for instance, is pretty universal as far as state laws go.
If you discover that you can legally use marijuana to ease your nausea, you will need to find a medical marijuana doctor.
Are there any Particular Medical Marijuana Strains that are Good for Nausea
The Indica dominant Chemo strain of marijuana was reputedly developed by Dr David Suzuki back in the 1970s for the specific role of treating the nausea and pain that is associated with chemotherapy treatment.
Users report a pleasant aroma – a very important factor when dealing with nausea. As far as flavor is concerned, when allowed to linger in the mouth, there is a distinctly sweet and sugary taste.
Chemo makes an excellent night time medicine as it helps with pain as well as nausea – it’s particularly good for relieving stomach pain. Because of its indica dominance (almost 100%) it does not leave behind any feelings of anxiety or paranoia.
If you live in a state where cultivation of medical marijuana is allowed, then Chemo is quick to flower and gives high yields – around 500 grams per square meter. Seeds are widely available.
Lots of good quality research together with pretty powerful anecdotal stories make it very difficult to ignore the fact that medical marijuana does help ease the symptoms of nausea.
Courtesy of the Medical Marijuana Blog
Rick Simpson has been providing people with Hemp Oil medicines, at no cost, for about years. The results have been nothing short of amazing. Watch the documentary Run From The Cure to understand more about using cannabis as a cure for cancer and other medical problems!
The long-term administration of delta-9-THC, the primary psychoactive compound in marijuana, is associated with decreased mortality in monkeys infected with the simian immunodeficiency virus (SIV), a primate model of HIV (human immunodeficiency virus) disease, according to in vivo experimental trial data published in the June issue of the journal AIDS Research and Human Retroviruses.
Investigators at the Louisiana State University Health Sciences Center assessed the impact of chronic intramuscular THC administration compared to placebo on immune and metabolic indicators of SIV disease during the initial six-month phase of infection.
Researchers reported, “Contrary to what we expected, … delta-9-THC treatment clearly did not increase disease progression, and indeed resulted in generalized attenuation of classic markers of SIV disease.” Authors also reported that THC administration was associated with “decreased early mortality from SIV infection” and “retention of body mass.”
Clinical trials have previously documented that the short-term inhalation of cannabis does not adversely impact viral loads in HIV patients, and may even improve immune function.
For more information, please contact Paul Armentano, NORML Deputy Director, at: email@example.com. Full text of the study, “Cannabinoid administration attenuates the progression of simian immunodeficiency virus,” is available online here:http://www.liebertonline.com/doi/pdf/10.1089/aid.2010.0218. Additional studies documenting the disease modifying potential of marijuana is available in the NORML handbook, Emerging Clinical Applications For Cannabis & Cannabinoids: Fourth Edition, available online at: http://norml.org/index.cfm?Group_ID=7002.
My name is No Inhale. I am 20 years old and I live in Portland, Oregon. I am part-owner and administrator for The Weed Blog. I don’t have a criminal record and I’m attending school full-time, but still people don’t think I am capable of leading a healthy and productive life. I’m not here to endorse smoking marijuana, nor am I here to convince anyone to try it. I am only asking those around me to, not only understand why I smoke cannabis, but accept it, as well.
I first smoked when I was a freshman in high school; I was 14 years old and just as blissfully unaware of my own ignorance as I am now. I didn’t like how it made me feel then, so I only did it a handful of times before quitting for the remainder of my high school career. I was approached by Johnny Green and Ninja Smoker in May of last year. They knew I supported those who used marijuana, but did not smoke it myself. This gave me enough credibility (and relevance) to start writing for the website. It’s a year later, and a few things have changed; mainly, that now I am, once again, a marijuana consumer.
I remember the petty judgments and shallow reception the “stoners” got in high school, but I always thought the animosity stemmed from 1,200 insecure teenagers forced to be around each other five days a week. Unfortunately, the adult world can be just as judgmental and closed-minded as a pack of 16 year old girls. Both sides of this issue are tired of the opposition’s repetitive rhetoric. Stoners, bible thumpers, rednecks, liberals, conservatives, hippies have all been beating their dead horses since June, 1971. It’s gotten so ridiculous that both sides are stretching the truth to serve their causes.
My time around cannabis culture has exposed me to hundreds of claims and “facts” about marijuana; many contradicting. What I have extrapolated from my experiences is much less dramatic than a painful death or a cure to all ailments. Marijuana is a plant; it grows naturally in the dirt. The fact that we have made nature illegal should show you how out of hand this has gotten. My father recently passed away from esophageal cancer. It was a three year battle of hell, but marijuana helped him enjoy his last years alive. I can’t imagine anyone would want to throw him in jail for trying to make his last years livable. Marijuana is not the cause of, nor the cure for, cancer, it’s just a plant that amplifies the positive emotions a person feels. Food tastes better, movies are more enjoyable, people are friendlier. Marijuana gives me a certain lucidity, a certain intimacy with everything around me, including myself. Sounds super stoney, right? So, who gives a shit?? Let me be a stoner. Let me laugh at Jay and Silent Bob, let me appreciate every-day objects as divine creation, let me see the beauty and symmetry this world has to offer. Why do you care? Let me enrich my life the way I want to. Let me roll my spliff and sink into my own subconscious, I promise you will come to see that marijuana is just another consumable this earth offers. No different from an apple, no different from chocolate cake, no different than salt and pepper. I don’t want you to join me (although you are always welcome), I just want you to understand and leave me to my happiness.